Scrum-half Fotuali'i was in from the off as the Islanders overcame Canada last weekend in Vannes - a game Pisi missed. The Saints flyer is back on Saturday afternoon though and lines up at full back for Manu Samoa as they play at Twickenham for the first time since 2010.
The pair will come up against clubmate Courtney Lawes, who starts a third Autumn International for England, while fellow Saints Dylan Hartley and Tom Wood are among the replacements.
The game kicks off at 7pm on Saturday evening and is live on Sky Sports 2HD.
SAMOA TEAM TO PLAY ENGLAND
Autumn International
Twickenham
Saturday, November 22nd, 2014
Kick off 7pm
15 Ken Pisi
14 Alapati Leiua
13 Reynold Lee-Lo
12 Johnny Leota
11 David Lemi
10 Tusi Pisi
9 Kahn Fotuali'i
2 Ti'i Paulo
3 Census Johnston
4 Filo Paulo
5 Kane Thompson
6 Maurie Fa'asavalu
7 Jack Lam
8 Ofisa Treviranus
Replacements
16 Manu Leiataua
17 Viliamu Afatia
18 Anthony Perenise
19 Fa'atiga Lemalu
20 Dan Leo
21 TJ Ioane
22 Pete Cowley
23 Mike Stanley