The pair both came off the bench in last weekend's dramatic 18-all draw against Tonga, and are two of seven changes made by the coaches ahead of the Azzurri's visit to Apia.
Pisi will join Alapati Leiua in their midfield while Fotuali'i is alongside Tusi Pisi in the half-backs.
Fa'atoina Autagavaia, who left the club at the end of the season, retains his place at full back.
SAMOA TEAM TO PLAY ITALY
Friendly
Apia Park, Apia
Saturday, June 14th, 2014
Kick off 2:00am UK time
15 Faatoina Autagavaia
14 Fautua Otto
13 George Pisi
12 Alapati Leiua
11 David Lemi (capt)
10 Tusiata Pisi
9 Kahn Fotuali'i
1 Logovii Mulipola
2 Tii Paulo
3 James Johnston
4 Faatiga Lemalu
5 Daniel Leo
6 Ofisa Treviranus
7 Jack Lam
8 Kane Thompson
Replacements
16 Wayne Ole Avei
17 Census Johnston
18 Sakaria Taulafo
19 Maurie Fa'asavalu
20 Piula Fa'asalele
21 Patrick Fa'apale
22 Vavao Afemai
23 Johnny Leota
